ATRA tretinoin

Tretinoin (1) is an RARa, (3 and y agonist and was the first retinoid approved for the treatment of acne and has been in clinical use for almost three decades. It is used as a 

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Also, it found that there is beneficial effect of ATRA in previous nonresponder patients with chronic hepatitis C since it has been suggested, from preclinical observations, that ATRA (tretinoin) has a potential antiviral activity against chronic hepatitis C infection. To assess efficacy, safety and tolerability of tretinoin in combination with pegin-terferon and ribavirin in genotype-l-infected patients with prior nonresponse, an open-label multicentre clinical trial... 

Tretinoin, also referred to ATRA, which stands for all-trans-retinoic acid, is a retinoic acid that is not cytotoxic but promotes the maturation of early promyelocytic cells and is specific to the t(15 17) cytogenetic marker. The time to peak concentrations is 1 to 2 hours after an oral dose. The elimination half-life is 21 to 51 minutes.32 These maroon-and-gold capsules are dosed at 45 mg/m2 per day divided into two doses. The most significant side effect is the retinoic acid syndrome, which may occur anywhere from the first couple of days of therapy until the end of therapy and consists of symptoms of... 

Tretinoin (aU-trans-retinoic acid, ATRA) is the carboxylic acid form of vitamin A (retinol). It is one of the first-generation retinoids and has been used since the 1970s to treat acne complaints and dyskeratosis. It is important to know all about this molecule in order to obtain benefit from its actions. 

Tretinoin (All-frans-retinoic acid [ATRA], Vesenoid) APL... 

ATRA (1) (Tretinoin) acne, photodamage, acute promyelocytic leukemia (AML) RAR agonist, protein synthesis antagonist, microbial collagenase inhibitor launched AP Pharma, Johnson Johnson, HofF-mann-La Roche, Myland Labs... 

The most important of these for cancer treatment is tretinoin (dll-trans retinoic acid ATRA), which induces a high rate of complete remission in APL as a single agent, and in combination with anthracydines, has become part of a curative regimen for this disease. 

Tretinoin is the acid form of vitamin A and so also known as aU-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. 

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