Atheroma, experimental

Kolodgie ED, Petrov A, Virmani R, Narula N, Verjans JW, Weber DK et al. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V a technique with potential for noninvasive imaging of vulnerable plaque. Circulation 2003 108 3134-3139... 

Galis ZS, Sukhova GK, Kranzhofer R, Clark S, Libby P (1995) Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A 92 402-406... 

A large and growing body of literature indicates that certain oxysterols, under given experimental conditions, exhibit strong pro-apoptotic properties against all types of vascular cells implicated in atheroma formation and development (Berthier et al. 2004 Pedruzzi et al. 2004 Poll et al. 2009 Vejux and Lizard 2009). 

We then repeated FTIR measurements on the diseased aortas from three additional ApoE ( —/ —) mice (3-month-old adult females) and two wild-type controls, and found similar results. These data support the hypothesis that the pathologic components within atheromas cause both the reflection of IR light and the characteristic absorption patterns observed in experimental atherosclerosis. 

Nature of arterial lipid depletion in regression of experimental coronary atheromas in Rhesus monkeys. 

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