Orlistat Atenolol

BETA-BLOCKERS ORLISTAT Case report of severe t BP when orlistat started on a patient on atenolol Uncertain at present Monitor BP at least weekly until stable... 

In a handful of ca e, patients taking enalapril and/or losartan and other antihypertensive drugs (amlodipine, atenolol, hydrochlorothiazide) had marked increases in blood pressure, hypertensive crises and, in one case, intracranial haemorrhage, within 7 to 60 days of starting orlistat. 

However, the manufaeturer has found no evidenee of an assoeiation between orlistat and hypertension. In elinieal studies, orlistat use was asso-eiated with a small reduetion in blood pressure eompaied with placebo, which was as a result of weight reduction. Moreover, the incidence of hypertension of new onset and hypertensive crisis did not differ between orlistat and placebo (1.2% versus 1.3%, and 0% versus 0.1%, respectively). In studies in healthy subjects, orlistat had no effect on steady-state losar-tan pharmacokinetics, and no clinically significant effect on the pharmacokinetics of single-dose captopril, atenolol, furosemide or nifedipine. ... 

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