AT hook

AT hook DNA-binding domain with preference for A/T-rich regions E(MFP)AB 5(6) 14(26) 2EZD... 

Fig. 1. Schematic diagrams based on the solution NMR structure of a complex of the second AT-hook motif of the human HMGAla protein bound to the minor groove of an AT-rich synthetic duplex DNA fragment [25], Various projected views of either the AT-hook peptide, or a co-complex of the peptide with DNA are shown (see text for details). Modified from Ref. [7].

Drugs that non-specifically compete with AT-hooks peptides for DNA-binding... 

Cairns, B.R., Schlichter, A., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D., and Winston, F. (1999) Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol. Cell 4, 715-723. 

Using Simpson s rule, the value of /o /dxA is 23.5s. At HOOK, the given molar feed rate of 0.25molAs together with the inert diluent, corresponds to a total volumetric feed rate of 0.564 m s . Thus... 

Example 5.19. This example shows how diffusivity may be inferred from natural samples. Suppose an Mg-Fe interdiffusion profile is measured in a mineral, and it can be modeled as a diffusion couple with I=60 pm. The temperature history is asymptotic with Tq = HOOK, and the cooling time-scale Tc= 10 Myr. Estimate the diffusivity at HOOK. 

Looking at Hooke s law, we can see that for a strong bond (large ) connected to a light mass it predicts a high-frequency (or wavenumber) vibration, and this is in agreement with the observed wavenumbers for the O-H and N-H absorptions (3600-3200 cm ... 

Fig. 35. Effect of N2 adsorption at 77 K on CO-precovered (low-0) LaCrC>3 samples out-gassed at HOOK for coverages ranging from 6 = 1 (5.33 kPa) to0 - 0. (left) nitrogen absorption region and (right) CO absorption region (unpublished data).

TABLE 2. Comparative rates and Arrhenius parameters for HF elimination of fluoroethanes at HOOK... 

Fig. 7. The conserved Zn module in Ace 1 and Mac 1 contains an RGRP motif that resembles the AT-hook domain of HMG-I(Y). In the HMG-I protein the RGR sequence adopts an extended structure that is buried deeply within the A/T minor groove (Huth et al., 1997). The two Arg residues of the motif are shown in spacefill as light gray and the Gly residue is shown as a dark spacefill.

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