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Stereoselective synthesis asymmetric transfer hydrogenation

Furo[3,4-7]pyridines can be prepared in a stereoselective synthesis involving a ruthenium-catalyzed asymmetric transfer hydrogenation reaction <2001TL1899>. The reaction proceeds with exceptionally high yield and ee (Equation 50). [Pg.312]

Application of ATH in Stereoselective Synthesis Murlcatacln can be isolated as a scalemic mixture from the seeds of Annona muricata Muricatacin and epi-muricata-cin showed anti-proliferative activity against certain cell Unes. The enantioselective total synthesis of a potent cytotoxic agent (- -)- p/-muricatacin was reported by Kumarasw-amy et employing Noyori catalytic asymmetric transfer hydrogenation of benzyl 128 to (15,25)-1,2-diphenylethane-1,2-diol, which subsequently reacted with 129 to produce a key chiral intermediate 130 (Scheme 30.26). [Pg.930]

Koike T, Murata K, Dcariya T. Stereoselective synthesis of optically active a-hydroxy ketones and anti-l,2-diols via asymmetric transfer hydrogenation of unsymme-trically substituted 1,2-diketones. Org. Lett. 2000 2(24) 3833-3836. [Pg.955]

Han J, Kang S, Lee HK. Dynamic kinetic resolution in the stereoselective synthesis of 4,5-diaryl cyclic sulfami-dates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation. Chem. Commun. 2011 47 (13) 4004- 06. [Pg.957]

Scheme 8.43)." The aldol reaction of aldehyde 272 and alkynylketone 273 catalyzed with Zn(ll)-265 complex gave (3-hydroxyketone 274 in excellent stereoselectivity. Noyori hydrogen transfer reaction provided the central diol moiety of fostriecin 278. They accomplished the asymmetric synthesis of 277, therefore, the formal synthesis of fostriecin 278. [Pg.236]


See other pages where Stereoselective synthesis asymmetric transfer hydrogenation is mentioned: [Pg.337]    [Pg.932]    [Pg.270]    [Pg.70]    [Pg.364]    [Pg.118]    [Pg.593]    [Pg.405]    [Pg.2127]    [Pg.343]    [Pg.70]   
See also in sourсe #XX -- [ Pg.930 , Pg.931 , Pg.932 , Pg.933 , Pg.934 , Pg.935 ]




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Asymmetric stereoselection

Asymmetric stereoselective

Asymmetric transfer

Asymmetric transfer hydrogenation

Hydrogen transfer stereoselectivity

Hydrogenation stereoselective synthesis

Hydrogenation stereoselectivity

Hydrogenation synthesis

Stereoselection hydrogenation

Stereoselective asymmetric hydrogenation

Stereoselective hydrogenation

Stereoselective synthesis

Stereoselectivity synthesis

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