Asymmetric hydrosilation catalysis

An important potential target of asymmetric hydrosilation catalysis is to the reduction of the cyclopenten-l,4-diones, 1, producing the 4-silyloxyeyclopentenones, 2, which are key intermediates in the synthesis of singleisomer prostaglandins (18-22). 

Asymmetric Synthesis by Homogeneous Catalysis Boron Hydrides Boron Organoboranes Hydrosilation Catalysis Rhodium Organometallic Chemistry. 

Ammonia N-donor Ligands Asymmetric Synthesis by Homogeneous Catalysis Decarbonylation Catalysis Hydride Complexes of the Transition Metals Hydroboration Catalysis Hydrogenation Isomerization of Alkenes Hydrosilation Catalysis P-donor Ligands Rhodium Organometallic Chemistry. 

Asymmetric catalysis by chiral rhodium complexes in both hydrogenation and hydrosilation have been found. Kagan (42) recently reported that the chiral phosphine rhodium complex [(—)-DIOPRhCl]2 gave the most efficient asymmetric syntheses observed to date. This complex is ... 

Asymmetric induction has been observed in the hydrosilation of prochiral olefins with optically active complexes as catalysis. See I. Ojima, K. Yamamoto, and M. Kumada, Aspects Homogen. Catal. 3, 185 (1977). 

During the process of hydrosilation two prochiral sp" hybridized atoms are converted to potentially chiral see Chiral) sp atoms. This opens up the possibility for asymmetric catalysis. The use of prochiral silanes of the type RR SiH2 also allows for the generation of chiral silanes. 

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