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Asymmetric Hydrogenation of Prochiral Olefins by Rhodium-DuPhos Catalysts

3 Asymmetric Hydrogenation of Prochiral Olefins by Rhodium-DuPhos Catalysts [Pg.127]

In 1995, Chirotech was successful in licensing the DuPhos technology from DuPont for commercial pharmaceutical applications, satisfying the industrially ready criterion of the intellectual property position, but at the time only gram quantities of a few catalysts had been made and applications were limited. It was our challenge to move this methodology [Pg.127]

4 Asymmetric Hydrogenation of Prochiral Ketones by Ruthenium-Bisphosphine-Diamine Catalysts [Pg.129]

To assure ourselves that we could meet aU the criteria required for the technology to be ready for industrial application, we investigated the practicalities in the asymmetric hydrogenation of acetophenone derivatives, using catalysts based on PhanePhos. Note that [Pg.130]

PhanePhos-based preoatalyst HexaPhemp-based precatalyst [Pg.131]




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Asymmetric Hydrogenation of Prochiral Olefins

Asymmetric hydrogenation catalysts

Asymmetric hydrogenation of olefins

Asymmetric olefination

Asymmetric rhodium

By Asymmetric Hydrogenation

Catalyst DuPhos

Catalyst asymmetric

DuPHOS hydrogenation

Duphos

Hydrogen olefinic

Hydrogenation of catalysts

Hydrogenation of olefins

Hydrogenation prochiral olefins

Of rhodium

Olefin asymmetric

Olefin hydrogenation

Olefin hydrogenation catalysts

Olefin hydrogenation rhodium catalysts

Olefins asymmetric hydrogenation

Olefins by hydrogenation

Olefins, prochiral

Prochiral

Prochiral asymmetrization

Prochirality

Rhodium asymmetric hydrogenation

Rhodium catalysts asymmetric

Rhodium catalysts catalyst

Rhodium catalysts hydrogen

Rhodium hydrogenation catalyst

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