Asymmetric Aldol Reactions of a-Isocyanocarboxylates

The gold(I) complex of a chiral ferrocenylphosphine complex promotes asymmetric aldol reactions of a-isocyanocarboxylates to form chiral oxazolines in high diastereo- and enantio-selectivities (Scheme 52).225,226 In these reactions, the analogous silver(I) ferrocenylphosphine complex also works well. [Pg.422]

B1.2. GOLD-CATALYZED ASYMMETRIC ALDOL REACTION OF a ISOCYANOCARBOXYLATES 495... [Pg.495]

TABLE 8B1.4. Gold-Catalyzed Asymmetric Aldol Reaction of a-Isocyanocarboxylates 9 with Aldehydes (Scheme 8B1.4)... [Pg.498]

Gold and Silver-Catalyzed Asymmetric Aldol Reactions of a-Isocyanocarboxylates... [Pg.586]

The catalytic asymmetric aldol reaction is tolerant of a-isocyanocarboxylates bearing an a-alkyl substituent (9a-d) as shown in Scheme 4 and Table 8B1.4 [17,18]. The enantioselectivities in the reaction with paraformaldehyde are generally moderate, with the exception of the... [Pg.496]

Asymmetric addition and insertion reactions of metal caibenes, 191-228 Asymmetric aldol reactions, 493-S12,704-705 mechanism of, 496 of a-isocyanocarboxylates, 493-502 of nitromethane, 503... [Pg.857]

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