Astragalus brachycentrus

PS from terrestrial plants have also been reported as anti-CMV agents. For example, PS from three plant species, Astragalus brachycentrus D. C., Astragalus echidnaeformis Sirjaev and Sterculia urens Roxb., which are devoid of in vitro antiviral activity, were evaluated in mouse models of murine CMV infections [109], Treatment with the compounds needed to be started one day prior to virus inoculation for maximum protective benefit. Treatments starting after virus inoculation were ineffective. The mannose-specific plant PS from the orchid species Cymbidium hybrid Cym., Epipactis helleborine (L) Crantz. and Listera ovata (L.) R.Br. Svenska are potent and selective inhibitors of human CMV in vitro [110], They presumably interact at the level of virion fusion with the target cell. 

Other natural PS should be considered for the potential treatment of significant human infections caused by bunyaviruses. The mouse model of Punta Toro virus, a Phlebovirus member of the Bunyaviridae family, is a model for studying the treatment of Rift Valley fever infection. Tragacanthin PS from Astragalus brachycentrus and Astragalus echidnaeformis plants caused reduction in mortality, liver infection scores, liver and spleen virus titers, and serum transaminases in treated mice [131],... 

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See also in sourсe #XX -- [ , , , , , , , , , ]

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