Associative Ligand Exchange at Square-Planar Platinum II

S-bonded isomers. Interconversion between the two isomers is slow on the NMR timescale in the absence of free dmso, a finding which casts doubt on some previous suggestions that dmso might enter coordination as an oxygen-bonded ligand and then isomerize. 

Associative Ligand Exchange at Square-Planar Platinum(II) 

The kinetic behavior of the anticancer drug Carboplatin, [Pt(NH3)2(biL)] (biL = 1,1-cyclobutanedicarboxylate), has been examined. In the absence of acid and other nucleophiles, the complex is quite inert. With addition of chloride. 

A study of some phosphineplatinum complexes by 2D exchange NMR spectroscopy has shown it to be a useful technique in detecting multiple exchange processes and in elucidating reaction mechanisms/ Where isotopomers are possible (e.g, Pt- P, Pt- Por Sn- P, Sn- P) the method differentiated between intermolecular and intramolecular processes. For example, the 2D exchange P NMR spectrum of complex (1) revealed exchange between P and 

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