Aspirin gastric irritation

Correct answer = C. Among the NSAIDs, aspirin is among the worst for causing gastric irritation. Aspirin is an effective analgesic and is used to reduce muscle pain. It also has antipyretic actions so that it can be used to treat fever. Because of its anti-inflammatory properties, aspirin is used to treat pain related to the inflammatory process, for example, in the treatment of rheumatoid arthritis. Low doses of aspirin also decrease the incidence of transient ischemic attacks. 

Oral administration of aspirin can result in gastrointestinal bleeding. The bleeding has been attributed to local irritation due to the acidic nature of the carboxylic acid substituent. In an attempt to reduce the gastric irritation of aspirin, acylal prodrugs were synthesized. In vitro, the prodrugs generated rapidly aspirin and in a... 

Subsequently there was enormous use of sodium salicyate as an ANALGESIC, ANTIPYRETIC and ANTIINFLAMMATORY (though a gastric irritant). This, in turn, prompted the synthesis of acetylsalicylic acid (aspirin), and subsequently the salicylate series of NSAID ANALGESICS, which later proved to work through being CYCLOOXYGENASE INHIBITORS. 

A number of aluminium aspirin preparations have also been described, to which different structures have been assigned . One of these compounds, aluminium aspirin NF, was found to be poorly absorbed compared with acetylsalicylic acid. Aloxiprin (Palaprin) is a different form of aluminium aspirin, being a polymeric condensation product of aluminium oxide and acetylsalicylic acid, with the formula Al302(C8H4(o-OCMe)-COO)s 9B. This compound is therapeutically as effective as acetylsalicylic acid it produces less gastric irritation and gastro-intestinal blood loss, but has a slight tendency to cause constipation. ... 

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