Aspartic acid biotechnological production

The microbial biotechnology of amino acids production which was developed and industrialized in Japan have been summarized. The amino acids include L-glutamic acid, L-lysine, L-threonine, L-aspartic acid, L-alanine, L-cysteine, L-dihydroxyphenylalanine, D-p-hydroxy-phenyl-glycine, and hydroxy-L-proline. 

Chibata I,TosaT, Sato T. Aspartic acid. In Aida K, Chibata I, Nakayama K,Takinami K,Yamada H, editors. Biotechnology of amino add production. New York Elsevier 1986. p. 144-51. 

Chibata, I., Tosa, T, Sato, T, 1986. Continuovis production of L-aspartic acid. Improvement of Productivity by both development of immobilisation method and construction of new recombinant Escherichia coli strain. AppUed Biochemistry and Biotechnology, 13,231-240. 

Sato, T., Mori, T., Tosa, T., Chibata, 1., Furui, M., Yamashita, K., Sumi, A., 1975. Engineering analysis of continuous production of L-aspartic acid by immobUized Escherichia coli cells in fixed beds. Biotechnology and Bioengineering 17,1797. 

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