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Asparagine synthetase, function

Many proteins have structures related to those of aminoacyl-tRNA synthetases.282 283 For example, asparagine synthetase A functions via an aspartyl-adenylate intermediate (Chapter 24, Section B), and its structure resembls that of aspartyl-tRNA synthetase.284 The his G gene of histidine biosynthesis (Fig. 25-13) encodes an ATP phosphoribosyltransferase with structural homology to the catalytic domain of histidyl-tRNA synthetase.284 The reason is not clear, but some aminoacyl-tRNA synthetases, especially the histidyl-tRNA synthetase, are common autoantigens for the inflammatory disease polymyosititis.285 286... [Pg.1698]

See other pages where Asparagine synthetase, function is mentioned: [Pg.384]    [Pg.324]    [Pg.437]    [Pg.164]    [Pg.216]    [Pg.296]    [Pg.52]    [Pg.385]    [Pg.1317]    [Pg.198]    [Pg.198]    [Pg.167]    [Pg.49]    [Pg.276]   
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