As antimalarial drug

Other derivatives of artemisinin are in various stages of clinical development as antimalarial drugs in Europe. 

Initially approved in the 1930s as antimalarial drug, quinacrine (2) became one of the first potential substitutes to quinine. The total synthesis of quinacrine would be achieved in 1931 by German scientists at Bayer,and it would be subsequently marketed as Mepacrine or Atebrine. However, quinacrine would soon be replaced by another synthetic and more efficient antimalarial drug, chloroquine (3). 

H Jomaa, J Wiester, S Sanderbrand, B Altincicek, C Weidemeyer, M Hintz, I Tur-bachova, M Eberl, J Zeidler, HK Lichtenthaler, D Soldati, E Beck. Inhibitors of nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285 1573-1576, 1999. 

Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Tiirbachova I, Eberl M, Zeidler J, Lichtenthaler HK, Soldati D, Beck E. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 1999 285 1573-1576. 

In a book about herbs, the Chinese scholar-emperor Shen Nung described in 2735 BC the beneficial effects of Ch ang Shan in the treatment of fevers [8]. This preparation is the powdered root of a plant, Dichroafehrifitga Lour. Modern medicinal chemistry has identified several alkaloids with antimalarial properties in the plant, and it is therefore clear that the ancient use of Ch ang Shan in fevers was not entirely without basis. One of the antimalarial compounds from Ch ang Shan is fihrugine (/J-dichroine), a relatively simple unichiral compound 1. Modem attempts to develop these agents as antimalarial drugs failed, due to significant toxicity [8]. 

Vaidya, A. B. (2004). Mitochondrial and plastid functions as antimalarial drug targets. Curr. 

A more interesting example is compound (IS), needed to make amines such as (16) for trial as antimalarial drugs.The OEt group is best left to appear in he starting material (guideline 6) so we have two strategies differing only in he order of events. 

Sweet wormwood contains the compound artemisinin. Artemisinin and compounds derived from sweet wormwood are widely used as antimalarial drugs (Meshnick 2002). 

No serious adverse events have been reported from artemisinin or artemisinin derivatives used as antimalarial drugs. Mild adverse events associated with the use of these compounds include nausea, vomiting, and diarrhea, although these have also been noted as symptoms of malaria (Gordi and Lepist 2004 McGready et al. 1998 Meshnick 2002 Meshnick et al. 1996 Ribeiro and Olliaro 1998). 

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