Aryl chlorides Kumada-Tamao-Corriu reactions

The reaction of aryl electrophiles with organomagnesium compounds is known as Kumada or Kumada-Tamao-Corriu reaction. The most common leaving groups in the electrophile are halogen atoms and, among them, chlorine is the most wanted due to the good availability and the low price of aryl or heteroaryl chlorides. Unfortunately, the oxidative addition of a metal center to an aryl chloride is a difficult reaction and many efforts have been made to overcome existing limitations. 

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