Arterial spin labeling

Perfusion Measurements with Arterial Spin Labeling 113... 

There are two ways to perform arterial spin labeling experiments The first one is the continuous spin labeling (CASL), where the blood is continuously inverted upstream. Therefore the magnetization within the tissue is in a steady state (Williams et al. 1992). The second class of ASL techniques is pulsed... 

Quantitation of the CBF can be an important factor in studies of therapeutic intervention. The method of arterial spin-labeled (ASF) perfusion MRI allows quantitative determination of the perfusion rate in units of ml/100 g tissue/min. However, the technique requires exceptional instrumental stability, as the result depends on accurate determination of the difference between tw o images on the order of a few percent. With the appropriate acquisition parameters to achieve sufficient signal to noise ratio (>100) and current instrument stability, this technique is feasible, especially in high field clinical systems. Currently, arterial spin-tagged perfusion measures are not widely used in clinical settings. 

Wang J, Alsop DC, Li L, Listerud J, Gonzalez-At JB, Schnall MD, Detre JA (2002) Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn Reson Med 48 242-254. 

Skeletal muscle perfusion in mouse leg was determined quantitatively, dynamically and noninvasively by NMR arterial spin-labeled(ASL) imaging. It was shown that despite the small size of the animal, mouse muscle perfusion may be measured, at rest and in conditions of reactive hyperemia, using saturation inversion recovery sequence, a pulsed ASL variant combined with NMR imaging. 

Golay X, Hendrikse J, Lim TC (2004) Perfusion imaging using arterial spin labeling. Top Magn Reson Imaging 15 10-27... 

Wang JJ, Hendrich KS, Jackson EK et al (1998) Perfusion quantitation in transplanted rat kidney by MRI with arterial spin labeling. Kidney Int 53 1783-1791... 

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