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Artemisinin biological targets

As described in this chapter, significant progress has been made in the elucidation of the chemical mechanisms of bioactivation and identification of potential biological targets of the antimalarial endoperoxide class of drug. Equally, medicinal chemists have had success in the preparation of both semi-synthetic artemisinin analogues and simplified... [Pg.1338]

Artemisinin (qinghaosu) antimalarial activity, 1309, 1313 biological targets, 1311-13 ESR spin-trapping agents, 1291 Feai) degradation, 1283, 1293, 1295-6 heme adducts, 1298, 1311-12 heterolyhc cleavage of peroxide bond, 1301-2, 1309... [Pg.1443]

This report on the mechanism of action of antimalarial artemisinin derivatives and the design of trioxaquines is an example of the key role of a biological metal complex (heme in the present case) acting both as trigger and target for the drug. [Pg.292]

See other pages where Artemisinin biological targets is mentioned: [Pg.225]    [Pg.1312]    [Pg.1313]    [Pg.1312]    [Pg.1313]    [Pg.178]    [Pg.76]    [Pg.1311]    [Pg.1311]    [Pg.190]    [Pg.227]    [Pg.289]    [Pg.289]    [Pg.293]    [Pg.294]    [Pg.15]    [Pg.282]    [Pg.288]   


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Artemisinin

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Biological targets

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