Biological Metal Ion Complexation

The ideas presented here merely scratch the surface of factors that control metal ion selectivity in biological systems. It is hoped that in future the picture will become even clearer, enabling us to learn much more about ligand design and selective metal ion complexation. 

Most of the topics reviewed in this chapter will be concerned largely with the structure, spectroscopic properties and reactivity of metal ions complexed to biological ligands, notably... 

Sigman DS, Landgraf R, Perrin DM, Pearson L (1996) Nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives. In Sigel A, Siegel H (eds) Probing of nucleic acids by metal ion complexes metal ions in biological systems Vol. 33. Marcel Dekker, New York, pp 485-513... 

There are important new applications of the aza-crown macrocycles for medicinal purposes. The perturbation of metabolic processes based on biological metal ion-ligand coordination can produce a disease or even death. Conversely, undesirable biological processes can be prevented by using certain metal ion-ligand interactions. For example, the weak complexing ability of chlorine to the central platinum ion of ds-platin (61) allows cw-platin to have antitumor activity (Haiduc and Silvestru, 1989). When applied in a biological... 

SiGEL A, Sigel H, eds. (1996) Metal Ions in Biological Systems. Vol. 33, Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules. Marcel Dekker, New York. 

Metal ions in Biological systems. Probing of nucleic acids by metal ion complexes of small molecules. Sigel, A., and Sigel, H., Eds. Marcel Dekker New York, 1996, Vol. 33. 

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