Antimalarial endoperoxides

As described in this chapter, significant progress has been made in the elucidation of the chemical mechanisms of bioactivation and identification of potential biological targets of the antimalarial endoperoxide class of drug. Equally, medicinal chemists have had success in the preparation of both semi-synthetic artemisinin analogues and simplified... 

Antimalarial endoperoxides biological targets, 1311-13 biomimetic Fe(II) chemistry, 1279-332, 1338, 1342... 

Carbenes, dioxirane preparation, 1132 Carbocations, antimalarial endoperoxides, 1309 Carbohydrate hydroperoxides, Mo-catalyzed olefin epoxidation, 432, 436 Carbohydrates, TBARS assay, 669 Carbonate esters, oxidative ozonolysis, 737, 738... 

Fenestrindane monoalcohol, C-H bond dioxirane oxygen insertion, 1162 Fenozan antimalarial endoperoxide degradation, 1292-3 iron(lV) oxo species, 1292, 1293, 1294, 1309... 

Lipid membranes, antimalarial endoperoxide targets, 1288, 1311-13 Lipid peroxides... 

Asawamahasakda, W., Ittarat, I., Pu, Y.-M., Ziffer, H., and Meshnick, S.R. Reaction of antimalarial endoperoxides with specific parasite proteins, Antimicrob. Agents Chemother., 38, 1854, 1994 Yang, Y.-Z., Little, B., and Meshnick, R. Alkylation of proteins by artemisinin effects of heme, pH, and drug structure, Biochem. Pharmacol., 48, 569,1994. 

Meshnick, S. R. Taylor, T. E. Kamchonwongpaisan, S. Artemisinin and the antimalarial endoperoxides from herbal remedy to targeted chemotherapy. Microbiological Rev.,... 

Meshnick, S.R., T.E. Taylor, and S. Kamchonwongpaisan. 1996. Artemisinin and the antimalarial endoperoxides From herbal remedy to targeted chemotherapy. Microbiol. Rev. 60(2) 301-15. 

Meshnick, S. R., Jefford, C. W., Posner, G. H., Avery, M. A., and Peters, W., Second-generation antimalarial endoperoxides, Parasitol. Today, 12, 79, 1996 (and references cited therein). 

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