Arsine oxide, Hydroxy-

CHLOROPHENYL)HYDROXYMETHYL- see CKD800 ARSINE OXIDE, DIBUTYLHYDROXY- see DDV250 ARSINE OXIDE, DIETHYLHYDROXY- see DIS850 ARSINE OXIDE, HYDROXY(2-HYDROXYPROPYL)PHENYL- see HNX600 ARSINE OXIDE, HYDROXYISOBUTYUSOPROPYL-see IPSlOO... 

Hydroxidimethyl arsine oxide 10% DC- Electron capture 200 on GasChrom Q Hydroxy dimethyl arsine oxide converted to iododimethyl arsine, then GLC, 92.3% recovery [719]... 

SYNS ARSINE OXIDE, (m-CHLOROPHENYL)-HYDROXY(P-HYDROXYPHENETHYL)- 2-PHENYL-2-HYDROXYETHYL, m-CHLOROPHENYL ARSINIC ACID... 

SYNS ARSINE OXIDE, (o-CHLOROPHENYL)(3-(2,4-DICHLOROPHENOXY)-2-HYDROXYPROPYL)-HYDROXY- (o-CHLOROPHENYL)(3-(2,4-DICHLOROPHENOXY)-2-HYDROXYPROPYL)-HYDROXYARSINEOXIDE... 

CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE see TGDOOO (m-CHLOROPHENYL)HYDROXY(P-HYDROXYPHENETHYL)ARSINE OXIDE see CKA575 (p-CHLOROPHENYL)HYDROXYMETHYLARSINE OXIDE see CKD800... 

The reaction of arsines with chloramine-T and related compounds gives rise to arsinimines (86,300) though these are usually isolated as the hydroxy sulfonamides (300,301,302). The hydrated compounds can also be prepared from the tertiary arsine oxide, or dihydroxide, and the appropriate amine. 

The previous arsinic acid in hydrochloric acid solution containing a little potassium iodide is saturated at 10 C. with sulphur dioxide and the gM passed for one hour. The addition of an equal volume of hydrochloric acid then precipitates 3-hydroxy-l 4-benzisoxazine-6-dichloro-arsine in 60 per cent, yield, but the product is difficult to purify. Solution in 2N sodium hy oxide and addition of hydrochloric add until only a faint acidity is shown to (Jongo red, causes the arsenoxide to separate in sphsero crystals, insoluble in water, dilute mineral acids, alkali carbonates, or dilute ammonia, but readily soluble in an excess of dilute caustic alkali solution. Treatment with excess of hydrochloric acid gives the dichloroarsine. 

Acetamido - 3 - hydroxy -1 4- benzisoxazine - 6 - arsinic acid may be prepared by acetylation of the corresponding amino-acid, or by chloraeetylation in alkaline solution of 8-amino-6-acetamido-4-hydroxyphenylarsinic acid. It crystallises in colourless prisms, M.pt. 275° to 280° C. with decomposition, and forms amorphous barium and magnesium salts. Reduction with sulphur dioxide and potassium iodide yields 8-acetamido-3-h.ydro.vy-l h-benzisoxazine-6-dichloroarsine in tufts of white needles, which are converted to the arsenoxide by water. The oxide forms clusters of white needles, insoluble in water, sodium carbonate, or dilute mineral acids, soluble in dilute sodium hydroxide and in aji excess of ION ammonium hydroxide. 

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