Array-based comparative genomic hybridization

DNA QUALITY EVALUATED BY ARRAY -BASED COMPARATIVE GENOMIC HYBRIDIZATION... 

Array-based comparative genomic hybridization (a-CGH) is a genomic analysis system that allows identification of alterations in DNA sequence and copy number, with a potential goal of individualized diagnosis and targeted cancer therapy.35,36 A number of reports have described application of a-CGH to DNA extracted from FFPE tissues, with variable results.35,37 38... 

DeVries S, Nyante S, Korkola J, et al. Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors. J. Mol. Diagn. 2005 7 65-71. 

Alterations in the gene copy number of miRNAs are detected in a variety of human cancers (41,42,43). Zhang et al. (41) showed that miRNAs exhibited high-frequency genomic alterations in human ovarian, breast cancer, and melanoma using high-resolution array-based comparative genomic hybridization. 

Tong CY, Hui AB, Yin XL, et al. Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization. J Neurosurg Spine. 2004 100 187-193. 

Wilhelm, M., Veltman, J.A., Olshen, A.B. et al.. Array-based comparative genomic hybridization for the differential diagnosis of renal cell cancer. Cancer Res., 62, 957-960, 2002. 

Sikela, J. Pollack, J. R. Interspecies cDNA array-based comparative genomic hybridization for identifying mammal genes having lineage specific variations in copy number. PCX Int. Appl. WO 2005023983, 2005 Chem. Abstr. 2005,142, 310878. 

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