Arousal dopamine

Baldo B. A., Daniel R. A., Berridge C. W., Kelley A. E. (2003). Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J. Comp. Neurol. 464, 220-37. 

Feenstra, M.G., Botterblom, M.H., van Uum, J.F. Behavioral arousal and increased dopamine efflux after blockade of NMDA-receptors in the prefrontal cortex are dependent on activation of glutamatergic neurotransmission. Neuropharmacology. 42 752, 2002. 

Dopamine D1 receptor DRDl Agonism May induce dyskinesia, extreme arousal, locomotor activation, vasodilatation and hypotension. Antagonism Tremor. 

Accordingly, several of the neurochemical and neuroanatomical systems considered to be involved in arousal and consciousness, i.e. Meynert nucleus, pontine reticular formation, locus coeruleus and raphe nucleus with their cholinergic, noradrenergic and serotonergic afferents (Delacourt, 1995) are affected in PD. In addition, the dopamine system, in particular the mesolim-bocortical system, is involved in cognition and motivation, and possibly in the emergence of positive psychotic symptoms such as hallucinations and delusions. 

Together with GFIB and ecstasy, amphetamines are often referred to as "club drugs," because they are increasingly popular in the club scene. They are often produced in small clandestine laboratories, which makes their precise chemical identification difficult. They differ from ecstasy chiefly in the context of use intravenous administration and "hard core" addiction is far more common with amphetamines, especially methamphetamine. In general, amphetamines lead to elevated catecholamine levels that increase arousal and reduce sleep, whereas the effects on the dopamine system mediate euphoria but may also cause abnormal movements and precipitate psychotic episodes. Effects on serotonin transmission may play a role in the hallucinogenic and anorexigenic functions as well as in the hyperthermia often caused by amphetamines. 

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