Aromatics, base properties vapor pressure, acids

In keeping with this method, several approaches have been developed to document methods and dose-response relationships for irritation in humans. This work suggests that, at least for nonreactive compounds such esters, aldehydes, ketones, alcohols, carboxylic acids, aromatic hydrocarbons, and pyridine, the percentage of vapor pressure saturation of a compound is a reasonable predictor of its irritant potency. Specific physical properties of molecules predict overall irritation potential. This work is based on the identification of irritant thresholds for homologous series of specific agents. Quantitative structure-activity relationships derived from such work suggests a reasonable model to explain mucosal irritation. 

Uses Skin softener, nonoily emollient for cosmetic creams/lotions, bath oils, blushers, skin fresheners, aftershaves, nail enamel removers binder lubricant dispersant emulsifier food-pkg. adhesives, coatings, paper, polymers defoamer for aq. systems, food contact, mold release applies., paints, ceramics, grinding fluids, hydraulic fluids lubricant base for textiles, paper, metalworking formulations chemical intermediate for fatty acid esters component for urethanes Regulatory FDA 21CFR 173.310,173.340(a)(3), 175.105,175.300,175.380, 175.390,176.170(a)(5), 176.180,176.200,176.210,177.1680,178.3740 Properties APHA40 max. liq., polyol odor sol. 5% in min. oils, min. spirits, aromatic soivs., perchloroethylene insol. in water m.w. 2000 sp.gr. 1.002 vise. 150-175 cst (100 F) vapor pressure < 0.1 mm Hg b.p. > 300 F acid no. 1 max. pour pt. -31 C flash pt. (PMCC) > 350 F ref index 1.450 100% act. 

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