Aromatic sulphonamides table

N spectra have been recorded for many sulphonamides, and some 15N NMR chemical shifts are given in Table 32. The aromatic sulphonamides in particular have... 

The melting points of sulphonamides, both aliphatic and aromatic, together with the melting points of some N-xanthylsulphonamides and sulphonacet-amides are collected in Tables 10.41 and 10.40. 

For melting points of sulphonamides derived from some of these aromatic hydrocarbons see Table 10.41. 

Accordingly, the spectrum of applicability of these CSPs can be derived. It appears that cellulose- and amylose-carbamate CSPs are excellent for the enantioseparation of SAs with hydrogen donor and/or acceptor sites (amides, carbamates, sulphonamides, hydroxy groups) as well as aromatic moieties, advantageously in combination with bulky groups close to the interaction sites. Due to the broad range of applicability a more detailed list of resolvable SAs would extend this report. However, further information is available from the application guide [172], from review articles [47,99,1(X), and from recently published enantioseparations (Table 9.4). 

Acetylation is an important route of metabolism for aromatic amines, sulphonamides, hydrazines and hydrazides and there is a wide variety of substrates. This metabolic reaction is one of two types of acylation reaction and involves an activated conjugating agent, acetyl CoA. It is hence a type 1 reaction. Acetylation is notable in that the product may be less water soluble than the parent compound. This fact gave rise to problems with sulphonamides when these were administered in high doses. The acetylated metabolites, being less soluble in urine, crystallized out in the kidney tubules, causing tubular necrosis (table 4,1). The enzymes which catalyse the acetylation reaction, acetyltransferases, are cytosolic and are found in the liver, in both hepatocytes and Kupffer cells, in the gastrointestinal mucosa and in white blood cells. The enzyme has been purified and its mechanism of action extensively studied and is now well understood. This involves first acetylation of the enzyme by acetyl CoA... 

TABLE 25. Substituent-induced shifts of aromatic carbons of some sulphonamides (<5CfiH6 = 128.5)... 

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