Aristolochia indica Ishwarane

A new type of. seco-ishwarane alcohol (724) has been identified in the roots of Aristolochia indica.326 This compound, which co-occurs with (+)-ledol (725), has antifertility properties when tested on mice. Its structure was deduced on the basis of spectral analysis together with its correlation with a derivative of ishwarane (726). A full report on the synthesis of ishwarone (727) has been presented.327... 

Ishwarane (20) and ishwarone (25) are two novel tetracyclic sesquiterpenes which have been isolated from Aristolochia indica Linn, and other tropical plants a synthesis of ishwarane was reported by Kelly and his co-workers in 1971. Kelly and Alward have now effected an improved synthesis of the hydrocarbon, which... 

Ishwaranes represent 7-11/10-12-bicycloeremophilanes. These rare tetracyclic sesquiterpenes are found in Aristolochiaceae, for example ishwarane itself and ish-waranol in the roots of Aristolochia indica and 3-ishwaranone from Aristolochia debilis. 

From the roots of Aristolochia indica, the tetracyclic sesquiterpenes ishwarane (252) and ishwarone (253) have been isolated (314). A few other related compounds are known. Biogenetically, they appear to be derived from the nootkatane cation (240). 

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