Insomnia aripiprazole

Aripiprazole (Abilify). Aripiprazole is indicated for the treatment of acute mania and for maintenance therapy. It is dosed at 5-30mg/day. Aripiprazole is well tolerated with the most common side effects being headache, agitation, anxiety, insomnia, and nausea. 

Daily doses of aripiprazole range from 5 to 30 mg. Aripiprazole is very well tolerated. Common side effects include headache, insomnia, nausea, dizziness, and constipation. 

The most common side effects associated with aripiprazole include headache, nausea, dyspepsia, agitation, anxiety, insomnia, somnolence, and akathisia. Dose-related adverse events include somnolence and akathisia. Early clinical experience indicates that akathisia may be avoided by starting the medication at doses lower than 10 mg and increasing the dose slowly. Aripiprazole is not associated with significant sedation, anticholinergic side effects, weight gain, or cardiovascular side effects (Petrie et al. 1997). 

Five patients (three women aged 30, 32, and 41 years and two men aged 36 and 56 years), had serious adverse effects developed after starting to take aripiprazole. There was agitation, akathisia, insomnia, and dysphoria three made suicide attempts and two had suicidal thoughts (10). 

Observational studies In a hospital-based postmarketing surveillance study 80% of 799 patients with schizophrenia from 122 psychiatric hospitals were treated for 4 weeks with aripiprazole 10-30 mg/day (mean modal dose 15 mg/day) [57 ]. There were significant improvements in clinical current scales and the most frequent adverse reactions were insomnia, irritability, restlessness, nausea, and vomiting. 

In a 12-week, multicenter, randomized, double-blind, placebo-controlled trial of aripiprazole in the treatment of alcoholism in 295 subjects, aripiprazole produced more positive subjective effects and less overall severity of alcohol dependence than placebo, although there was no difference between aripiprazole and placebo on the primary end-point, possibly because of dose-related attrition (treatment was started at 2 mg/day and titrated to a maximum of 30 mg/day at day 28). Withdrawals (40% versus 27%) and treatment-related adverse effects (83% versus 64%) were more common with aripiprazole. The most common treatment-related adverse events that differed significantly between aripiprazole and placebo were fatigue, insomnia, restlessness, somnolence, anxiety, and altered attention serious adverse reactions attributed to aripiprazole were chest pain, cellulitis, migraine, and thrombosis extrapyramidal adverse reactions attributed... 

Consider short-term s5nnptomatic relief for agitation or insomnia, particularly if using a nonsedative antipsychotic (aripiprazole/amisulpride) e.g. 

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