Arginine lipopeptide surfactant

Arginine Lipopeptide Surfactants with Antimicrobial Activity... 

Water-soluble antimicrobial Upopeptides have been prepared by the condensation of amino acids or peptides to lV -acyl arginine residues with suitable lipophilic contents. Our data suggest that such arginine lipopeptidic surfactants have value as soft preservatives in cosmetic, food, and dermopharmaceutical formulations, as well as being tools for fundamental research. 

This chapter describes their synthesis on a laboratory scale, some of the properties of noncommercial antimicrobial lipopeptidic surfactants derived from At -acyl arginine, and the relationships between antimicrobial function and the chemical structure of the hydrophobic and hydrophilic moieties. 

FIG. 2 Structures of lipopeptidic surfactants synthesized from arginine (a) pure lauroyl-L-arginine dipeptides (b) polydisperse Al -acyl-L-arginine dipeptides (c) poly-disperse Al -acyl-L-arginine peptides. 

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