Arg-Gly-Asp , tripeptide

Figure 4.2 Synthesis of the copolymers of L-lactic acid and BMD and DMD functionalized with pendant ester group and immobilized with cell-binding arg-gly-asp tripeptide (RGD) [21]...

Technetium-labeled peptides and proteins have been investigated as potential thrombus-imaging agents. Complex 70, which combines 99mTc with the tripeptide motif Arg-Gly-Asp, binds GP Iib/IIIa recep-... 

It is suggested that the bicyclic diastereoisomeric fr.mr-azetidine 519 is a convenient nonpeptidic framework which mimics the /3-turn topology of the Arg-Gly-Asp (RGD) tripeptide portion of the extracellular matrix protein, fibronectin, involved in cell adhesion <2003BML1561>. 

An example of the use of peptidic information comes from the work of Pickett et al. (76) using the known tripeptide RGD (Arg-Gly-Asp) (see Fig. 5.11) motif fibrinogen uses for receptor binding (86). A database of 100,000 compounds, which had been seeded with fibrinogen receptor antagonists covering a wide range of structural classes (see Fig. 5.12), was... 

K. S., and Rahman, S. (1994). Preferential antagonism of the interactions of the integrin a,npj with immobilized glycoprotein ligands by snake-venom RGD (Arg- Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RGD in determining the inhibitory properties of snake-venom RGD proteins. Biochem J. 5(34 929-936. 

The trIpeptIde RGD sequence (Arg-Gly-Asp), found In fibronectins and some other matrix proteins. Is recognized by several Integrlns. 

Also glycoporphyrin biological properties can be enhanced in a compoimd of that type if it is coupled with certain peptides. Indeed, it was shown that certain tripeptides, like Arginine-Glycine-Aspartate (Arg-Gly-Asp RGD motif), linked to a chemotherapeutic molecule (doxorubicin), helps the drug to reach the new blood vessels that nourish the tumor [ 125]. 

Protease-catalyzed synthesis of two precursor dipeptides of the hydrophilic tripeptide RGD (Arg-Gly-Asp) in three different types of w/o microemulsions, namely AOT/isooctane, Triton/ethyl acetate, and CTAB/heptane/hexanol, was reported by Chen and coworkers [59]. RGD is a tripeptide of pharmaceutical interest consisting of one neutral (Gly) and two hydrophilic amino acids (Arg and Asp). Among the proteases tested, alcalase and trypsin were selected as the most efficient catalysts and the reverse micellar system consisting of... 

As an alternative, Pluronic F127 has also been modified with maleim-ide groups followed by subsequent reaction with the tripeptide Arg-Gly-Asp (RGD) containing peptides. The peptide-modified, thermo-responsive hydrogels were hydrolytically stable and presented an attractive material... 

A sialyl-Lewis conjugate with the tripeptide Arg-Gly-Asp has been prepared by way of a tetrasaccharide glycosylazide using conventional glycosidation reactions, reduction to the glycosamine and coupling with a C-terminal free peptide. In a cell adhesion test, this conjugate was the best competitive inhibitor... 

In the al-chain of hide collagen, there are even many tripeptides containing positive as well as negative charges. This is shown by the occurrence of the following sequences Gly-Glu-Arg = 10 times, Gly-Glu-Lys = once, Gly-Asp-Arg = 4 times, Gly-Asp-Lys =... 

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