Areas for future investigation

Some Particular Areas for Future Investigations on Protein Deteriorations... 

The following are some possible areas for future investigations of protein deteriorations ... 

Spruston It s clear that different isoforms have different properties. This is an important area for future investigations. Those of us who are interested in the CNS and specialization of firing properties would like to know more about how different isoforms have an effect. Another really important factor may be the interaction of the Na channels with the cytoskeleton itself, through things like AKAPs (A-kinase anchoring proteins) and with extracellular elements through the j subunits, and how this affects Na channel properties. Clearly, every cell in the CNS is different, and the Na channels are rarely alike in any two types of neurons. 

However, time-resolved optical spectroscopy is perhaps the premier method for learning about the dynamics of a complex system, especially on nanosecond or picosecond time scales. Some DNA dynamics data from NMR spectroscopy are presented in Table 4.3. Time-resolved emission decays, time-resolved fluorescence anisotropy, and time-resolved Stokes shifts measurements of probe molecules in DNA have been described (and see below) and fast components in the time decays assigned to various DNA motions. The dynamics as a function of sequence are incompletely mapped and provide an exciting area for future investigations. 

LaGreca, A. M. (1990). Social consequences of pediatric conditions Fertile area for future investigation and intervention Journal of Pediatric Psychology, 15, 285-307. 

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