Are Humans at Risk

It is biologically plausible that exposure to a sufficient level of an oestrogenic chemical could cause harmful biological effects. However, it is far more difficult to establish that environmental oestrogens are responsible for adverse effects on 

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Luebke, R.W., Pesticide-induced immunotoxicity Are humans at risk, Human Ecol. Risk Assess., 8, 293, 2002. 

More recently, however, in cynomologous monkeys, a nonhuman primate, some limited responses to these compounds have been seen with a twofold increase in liver weight, hepatocyte hypertrophy, an increase in peroxisomes (2.7x), and an increase in mitochondria. However, no DNA damage was detected. With humans taking ciprofibrate, only limited peroxisome proliferation was seen, and there was no increase in acyl CoA oxidase. Thus, the question is, "are humans at risk " In order to understand this, the mechanism needs to be understood. 

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