Arachidonoylglycerol biosynthesis

Di Marzo V, Bisogno T, De Petrocellis L, Melck D, Orlando P, Wagner JA, Kunos G. Biosynthesis and inactivation of the en-docannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur. J. Biochem. 1999 264 258-267. 

Figure 10.6. The biosynthesis of endocannabinoids. Biosynthetic pathways for the biosynthesis of the major endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG). Note that the enzymes N-acyltransferase in anandamide biosynthesis. The biosynthesis of 2-AG can proceed via two different routes and is also dependent on an increase in Ca. Figures reprinted from Piomelli (2003) with permission from Nature Publishing Group.

Bisogno T, Sepe N, Melck D, Maurelli S, De Petrocellis L, Di Marzo V (1997) Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells. Biochem 1 322 671-677... 

Sugiura T, Kobayashi Y, Oka S, Waku K (2002) Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids 66 173-192... 

FIGURE 5.1 Proposed model for the possible role of 2-arachidonoylglycerol (2-AG) in the synapse. (From Sugiura, T., Kondo, S., Kodaka, T., Nakane, S., Yamashita, A., Kishimoto, S., Waku, K., and Ishima, Y. [1998] Biosynthesis and actions of anandamide and 2-AG two endogenous cannabimimetic molecules, in Essential Fatty Acids and Eicosanoids, Eds., R.A. Riemesma, R. Armstrong, W. Kelly, and R. Wilson, Champaign AOCS Press, pp. 380-384. With permission.)... 

Di Marzo, V., Bisogno, T, DePetrocellis, L., Melck, D., Orlando, R, Wagner, J.A. et al. (1999). Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. European Journal of Biochemistry, 264 258-267. 

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