Arachidonic acid metabolites vasoconstricting

Gurtner, G.H., Knoblauch, P., Smith, L., Sies, H. and Adkinson, N.F. (1983). Oxidant-and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites. ]. Appl Physiol, 55, 949-954... 

In addition, Ang II rapidly phosphorylates and activates PLA2 to produce arachi-donic acid (Rao et al. 1994). Cytochrome P450 metabolites of arachidonic acid, such as 20-hydroxyeicosatetraenoic acids (20-HETEs), have been implicated in vasoconstriction in various vascular beds (Roman 2002). 

Dual inhibitors also demonstrate other therapeutical benefits. They reduced the coronary vasoconstriction in arthritic hearts in a rat model [101], and significantly decreased angiotensin II-induced contractions in human internal mammary artery [102], Opioid receptor activation can cause a presynaptic inhibition of neurotransmitter release mediated by LOX metabolites of arachidonic acid in midbrain neurons. The efficacy of opioids was enhanced synergistically by treatment of brain neurons with COX and LOX dual inhibitors. This report might lead to development of CNS analgesic medications involving combinations of lowered doses of opioids and COX/LOX dual inhibitors [103]. The COX and 5-LOX dual inhibitors also can prevent lens protein-induced ocular inflammation in both the early and late phases [104]. 

Prostaglandins (PGs) and thromboxanes are metabolites of arachidonic acid produced through the cyclooxygenase pathway. Some PGs have vasoconstrictive and/or bronchodilatory properties, whereas others are vasodilatory (e.g., PGD2) and/or bronchoconstric-... 

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