Cytosine arabinoside triphosphate

ADCC ADP AM ara-C ATP BAPTA antibody-dependent cellular cytotoxicity adenosine diphosphate acetoxymethyl ester cytosine arabinoside adenosine triphosphate bis- (o-aminophenoxy)-ethane-N,N,N, N -tetraacetic acid... 

This enzyme [EC 2.7.1.74] catalyzes the reaction of a nucleoside triphosphate with deoxycytidine to produce a nucleoside diphosphate and dCMP. This enzyme can use any nucleoside triphosphate (except dCTP) as the phosphate-donor substrate and it can phosphorylate cytosine arabinoside as well. 

Cytarabine is an effective antimetabolite in treating leukemia. Like other pyrimidine antimetabolites, cytarabine must be activated by initially transforming into the corresponding nucleotide. The active form of the drag is cytarabine triphosphate. Cytarabine is used for all types of leukemia. Synonyms of this drug are cytosine, arabinoside, and ara-C. 

Cytarabine (cytosine arabinoside, ara-C) is an S phase-specific antimetabolite that is converted by deoxycytidine kinase to the 5 -mononucleotide (AraCMP). AraCMP is further metabolized to the triphosphate (AraCTP), which competitively inhibits DNA polymerase and results in blockade of DNA synthesis. Cytarabine is also incorporated into RNA and DNA. Incorporation into DNA leads to interference with chain elongation and defective ligation of fragments of newly synthesized... 

Site of action Like the other purine and pyrimidine antagonists, ara-C must be sequentially phosphorylated to the corresponding nucleotide, cytosine arabinoside triphosphate (ara-CTP), in order to be cytotoxic. It is S-phase (hence cell-cycle) specific. Ara-C is also incorporated into DNA and can terminate chain elongation. It can also inhibit the reduction of CDP to dCDP. 

High Performance Liquid Chromatography.—This technique has been applied to a wide range of natural products, i.e., steroidal phosphates, retinyl phosphate, dansylated protein hydrolysates, thiamine phosphates, dibutyl c-AMP esters, cytosine arabinoside triphosphate, and di- and tri-nucleoside phosphates. ... 

NTP -I- deoxycytidine = NDP -I- dCMP (cytosine arabinoside can act as acceptor, all natural nucleoside triphosphates except dCTP can act as donors <3, 7> mechanism [12, 22, 30, 43] <3> ordered A-B random B-Q reaction sequence [30] <3> random bi-bi mechanism [38])... 

Cytosine arabinoside p-D-Furanose-/orw 5 -Phosphate, C-221 Cytosine arabinoside p-D-Furanose-/orw 5 -TViphosphate, C-221 2 -Deoxy-5 -adenylic acid, D-28 2 -Deoxyadenosine 5 -Diphosphate, D-28 2 -Deoxyadenosine 5 -TViphosphate, D-28 2 -Deoxy-3 -adenylic acid, D-28 2 -Deoxyadenylyl-(3 ->50-2 -deoxyguanosine, D-31 2 -Deoxycytidine -D-form 5 -Diphosphate, D-43 2 -Deoxycytidine -D-form 5 -Phosphate, D-43 2 -Deoxycytidine -D-form 5 -Triphosphate, D-43 2 -Deoxy-3 -cytidylic acid, D-43 2 -Deoxycytidylyl-(3 50-2 -deoxyadenosine, D-45 2 -Deoxycytidylyl-(3 50-2 -deoxyadenylyl-(3 50-2 -deoxyguanosine, D-46... 

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