Aquatic species, xenobiotic conjugation

Many investigations of relevant enzymes in transformation of xenobiotics by aquatic species have shown that the similar enzymes observed in metabolism in soil, plant, and mammals play a role, such as esterases and oxidases [10, 159, 160]. Metabolism of pyrethroids has been most extensively studied in fish for cypermethrin (5) and permethrin (15). Aromatic hydroxylation at the 4 -position of the 3-phenoxybenzyl moiety followed by conjugation with glucuronic acid... 

To summarize, several studies have demonstrated the ln iortance of conjugation reactions in determining the fate of xenobiotics in aquatic am mala. Among fish, most Information had been gained in the trout, the southern flounder, the winter flounder and the dogfish shark. It is evident that there are considerable Interspecles differences in the ability of fish to conjugate xenobiotics, as is true for other species, but the major pathways of conjugation are similar in all animal species studied. 

---