Aptamers for the Design of an Affinity CE-Based Enantioselective Competitive Assay

2 Aptamers for the Design of an Affinity CE-Based Enantioselective Competitive Assay 

D- and L-arginine were injected as a sample plug over the concentration range 

01% of the minor enantiomer in a noiaacemic mixture, one order of magnitude lower than the 0.1 to 1% detection limits, which are typically attainable with currently available stereoselective analysis methods. 

Second, it is easy to reverse the enantiomeric elntion order through the change in configuration of the selector or the enantiomer nsed as target. This appears of very great interest for the determination of enantiomeric excess. 

Brumbt, A., Ravelet, C., Grosset, C., Ravel, A., Villet, A., Peyrin, E. (2005). Chiral stationary phase based on a biostable l-RNA aptamer. Anal Chem 77, 1993-1998. 

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