APSAC anistreplase/anisoylated

Anistreplase (anisoylated plasminogen streptokinase activator complex APSAC) consists of a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme s active site. When administered, the acyl group spontaneously hydrolyzes, freeing the activated streptokinase-proactivator complex. This product (recently discontinued in the USA) allows for rapid intravenous injection, greater clot selectivity (ie, more activity on plasminogen associated with clots than on free plasminogen in the blood), and more thrombolytic activity. 

Anistreplase (anisoylated plasminogen streptokinase activator complex, APSAC), is the plasminogen-streptokinase complex (above) in which the enzyme centre that converts plasminogen to plasmin is protected from deactivation, so prolonging its action. 

Anisoylated plasminogen streptokinase activator complex (APSAC, anistreplase)... 

Commonly used thrombolytics are streptokinase, urokinase, tissue plasminogen activator (t-PA, Alteplase), anisoylated plasminogen streptokinase activator complex (APSAC, Anistreplase), and reteplase (Retavase). 

Anistreplase This anisoylated plasminogen-streptokinase activator complex (APSAC) is a prodrug. As the anisoyl group is hydrolyzed in vivo (a slow, spontaneous process), the... 

Unfortunately, the half-life of the activator complex is less than 30 minutes, which frequently is too short to completely lyse a thrombus. Anistreplase (APSAC Eminase) is a 1 1 streptokinase/lysine-plasminogen complex that has been acylated with an anisoyl group at the active-site serine within... 

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