Rifampicin Aprepitant

APREPITANT RIFAMPICIN 1 aprepitant levels Induction of CYP3A4-mediated metabolism of aprepitant Watch for poor response to aprepitant... 

Clinically important, potentially hazardous interactions with aprepitant, astemizole, carbamazepine, colchicine, cyclosporine, dihydroergotamine, ergot alkaloids, ergotamine, erythromycin, fluoxetine, fluvoxamine, methylprednisolone, methysergide, oral contraceptives, paroxetine, pimozide, prednisolone, rifampicin, sertraline, solifenacin, terfenadine, warfarin... 

Rifampicin markedly reduced the AUC of aprepitant, and reduced efficacy would be expected. In the UK, the manufacturer recommends that concurrent use of aprepitant and other strong inducers of CYP3A4 should be avoided. 

The manufacturers note that when a single 375-mg dose of aprepitant was given on day 9 of a 14-day regimen of rifampicin 600 mg daily, the AUC of aprepitant was decreased about 11-fold (91%), and the half-life about threefold (68%). ... 

Rifampicin is an inducer of the eytoehrome P450 isoenzyme CYP3A4, by which aprepitant is metabolised. Coneurrent use therefore decreases aprepitant levels... 

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See also in sourсe #XX -- [ ]

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