Applications to oligosaccharides

A study by Prestegard and co-workers on a trisaccharide molecule, methyl 

In another study, Freedberg employed RDCs to investigate the conforma- 

54° and 72°). The observation that multiple conformers agreed with the RDCs was interpreted as evidence for having limited but nevertheless multiple and dynamically interconverting sugar pucker conformations. 

There are also tremendous possibilities for using RDCs as a direct probe of conformational dynamics. Recalcitrant problems such as the characterization of intermediate timescale motions (microsecond-nanosecond), both for 

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Carboxybenzyl Glycosides A Novel Type of Glycosyl Donors and Their Application to Oligosaccharide Synthesis... 

This year has seen a number of mass spectrometric applications to oligosaccharide characterizations. Uqmd secondary ion mass spectrometry (LSIMS) has been used in characterization of tetra-, hexa- and octasaccharides derived from porcine intestinal heparin. Laser desorption time-of-flight MS of heparin fragments complexed with (Arg-Gly)io and (Arg-Gly)is overcomes the problem... 

Different instruments are now available for automated synthesis on solid phase. The Applied Biosystems peptide synthesizer ABl 433 (Fig. 3) was chosen as an initial platform due to its wide availability and the few modifications necessary for its application to oligosaccharide synthesis. The custom-made reaction vessel is constructed of jacketed glass to allow cooling. The building blocks are placed in cartridges to be delivered sequentially. The synthesizer allows for nine different solvents and reagents. A new, more versatile and less... 

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