Pharmaceutical applications compression effects

The primary use for dibasic calcium phosphate in pharmaceutical applications is as a tablet or capsule diluent. It is also used as an excipient for direct compression formulations of hard tablets requiring a good disintegrant and an effective lubricant. It has limited use as a mineral supplement for calcium replenishment. Diluents often comprise the bulk of the tablet formulation, with use levels between 40 to 90 % of the tablet weight. It has also foimd use as an adsorbent and as a thickening agent in creams and ointments. The pharmacopeial specifications for Dibasic Calcimn Phosphate USP are as follows ... 

Lack of biocompatibility [39] was mentioned but seems to be now reconsidered there is few applications in biomedical domain. The main applications are in food [40] as a thickener or stabilizer of emulsions. They are also used in personnal care, cosmetic and pharmaceutic compositions and household care products for which there are many patents [37, 41,42]. Low molecular weight sulphated derivatives of galactomannan have anticoagulant activity[28]. Different pharmaceutical applications are mentioned in the literature as example for blood glucose-lowering effect[43], or to produce tablets by compression and control the release of drugs [44-46]... 

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