Applications of NMR-Spectroscopy in Pharmaceutical Analysis

NMR-spectroscopy has been extensively employed for the identification testing as well as quantitative analysis of pharmaceutical substances. These two aspects shall be discussed in the sections that follow  

The versatility and ability of NMR to distinctly differentiate nuclei in various intramolecular environments has placed it as the most reliable and dependable technique for carrying out the identification testing of a host of pure drugs. Hence, any apparent deviations of the spectrum of a sample under investigation vis-a-vis the spectrum of the pure and the authentic pharmaceutical substance usually give rise to an enormous information not only confined to the true identity of the substance but also the probable nature of the impurities it possesses. 

The survey of literature provides ample evidence of the NMR spectra of a good number of medicinal compounds belonging to various categories, namely sulphonamides barbiturates amphetamines steroids antihistamines penicillins and cephalosporins to name a few. 

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