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Applications of Blood Drug Measurements

It is difficult to overestimate the potential contribution to the understanding of the mode of action, pharmacological effects and therapeutic usefulness of drugs that can be made by measuring their concentration in blood and tissues. Nevertheless, at the present time the practical value of such measurements for monitoring and regulating drug therapy in individual patients is limited and does not fully justify the more optimistic forecasts of their potential usefulness. Some of the reasons for caution have already been mentioned, and others are discussed later in this chapter. [Pg.64]

It should be possible, however, to predict those drugs for which plasma measurements are likely to prove most useful. (1) The drug should show a more or less close correlation between its concentration in the plasma and its therapeutic effectiveness and/or toxicity (see below) (2) the disease for which the drug is used must be of sufficient duration to make [Pg.64]

This subject has recently been extensively reviewed (B22, B23, LI), and only the most salient points will be discussed here. [Pg.65]

Because of its greater sensitivity many drugs arc amenable to measurement by spectrofluorimetry at the low concentrations at which they occur [Pg.65]

VINCENT MARKS, W. EDWARD LINDUP, AND E. MARV BAYLIS [Pg.66]


See other pages where Applications of Blood Drug Measurements is mentioned: [Pg.47]    [Pg.64]   


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