Applications autoanalyzer systems

Direct spectrophotometric analysis of chlordi-azepoxide has not been found to be applicable if significant quantities of the known hydrolytic contaminants are present. For material not containing the interfering species the reported maxima at 245-6 nm and 311-12 nm in acidified 3A alcohol may be used for quantitative measurements. The a values at these maxima are 110.9 and 34.2 respectively. The Technicon Autoanalyzer system for dosage form assays of chlordiazepoxide is based on the direct spectrophotometric assay. 

Analmatic2B and Autoanalyzer.30 The Analmatic system appears to have been initially designed for industrial laboratory operation, yet its flexibility of design if not the cost could allow for adaptation to clinical chemical procedures. The Autoanalyzer was initially designed for clinical chemical procedures with sufficient flexibility for industrial laboratory adaptation. Since more information concerning the use of the Autoanalyzer in clinical chemistry is presently available, relatively more discussion will be devoted here to its application. 

Automatic Continuous-Flow Analysis. At the time of writing, the only system of automatic analysis to have gained widespread acceptance in clinical chemistry laboratories employs the principle of continuous flow devised by Skeggs (S4) and incorporated into the AutoAnalyzer. Application of the AutoAnalyzer to large batches of samples can materially improve the reproducibility of the results (Section 6.2). The principles of the AutoAnalyzer are by now well known and do not require recapitatulation relevant features of the functioning of the basic process modules will, however, be discussed. Other more specialized modules... 

Concerning the preanalytics that have to be used, two main concepts are available for the application of enzyme electrodes to different fields of analysis. Clinical chemists nowadays are interested in autoanalyzers characterized by high measuring frequency as well as in portable bedside-type analytical systems with extremely short lag time between sample withdrawal and analysis result. On the other hand the optimal control of food production as well as bioprocesses requires the analysis of the substances of interest in a continuous or quasicontinuous way. Therefore, enzyme-electrode-based analytical systems for the application of highly diluted as well as undiluted media have been developed and commercialized. 

The application of autoanalyzers and FIA systems for bioprocess control has gained more and more importance Several wet chemical or biochemical assays can be run automatically... 

Clinical chemists are interested in autoanalyzers characterized by high measuring frequency as well as in portable bedside-type analytical devices with short lag time between sample withdrawal and availability of the result. Therefore, enzyme electrode-based analytical systems for the application of highly diluted as well as undiluted media have been developed and commercialized. 

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