Application to Chemical Reactivity of Drug Glucuronides

This directly coupled HPLC-NMR method has been used to investigate the acyl migration kinetics of individual isomers of 2-, 3- and 4-fluoro-, and 2- and 3-trifluoromethylbenzoyl-D-glucopyranuronic acid separated from an equilibrium mixture of the (3-1-O-acyl isomer, the a- and [3-2-0-acyl isomers, the 

The acyl migration of the glucuronide metabolite of the model drug 6,11-dihydro- 11 -oxodibenz (b,e) oxepin-2-acetic acid has also been investigated in urine and pH 7.4 buffer using directly coupled 600 and 750 MHz stop-flow HPLC H NMR spectroscopy [53,54], 

More recently, the acyl migration reaction has been studied for a range of non-steroidal anti-inflammatory compounds. For example, a detailed study has 

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