Application of the Hydroformylation-Acetalization Tandem Reaction in Practice

Application of the Hydroformylation-Acetalization Tandem Reaction in Practice 

In principle, the hydroformylation-acetalization sequence can be performed in two separate steps as sometimes described in the older literature. Thus, hydroformylation of cyclohexene was carried out with Co2(CO)g as catalyst at 180 bar syngas pressure [45]. The formed aldehyde was separated from the catalyst and subsequently reacted with ethylene glycol in the presence of sulfuric acid to give the corresponding cyclic acetal.  

1) Because of its fruity, apple-like odor, it was used to create new perfume compositions in a mixture with other flavoring compounds. 

More interesting seems to be the hydroformylation-acetalization in one pot under the same conditions as a tandem reaction. In this regard, two aspects must be differentiated undesired and desired acetalization after the hydroformylation step. 

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