Application of Sparse Sampling and Population Kinetic Methods

Application of Sparse Sampling and Population Kinetic Methods 

There have been attempts to study the pharmacokinetics of macromolecules by applying the sparse sampling strategy and population kinetic methods described in Chapter 10 (36, 77). In one study, erythropoietin was administered SC to 48 healthy adult male 

FIGURE 32.12 RelationsUp behA een G-CSF clearance and absolute nentrophil count (r = 0.85, P = 0.00025). The dotted lines represent the 95% confidence intervals of the regression. (Reproduced with permission from Ericson SG et al. Exp Hematol 1997 25 1313-25.) 

Population PK methods also were used to analyze the concentration-vs-time profiles of IFNa in 

TABLE 32.16 Characteiistics That Affect the Pharmacokinetics of Macromolecules 

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