Application in the Synthesis of Pharmaceutically Active Ingredients

Three-step chemoenzymatic synthesis of the anticholinergic drug (S)-rivastigmine. 

Biocatalytic routes for the preparation of the antidiabetic drug sitagliptin (a) and the antiarrhythmic agent vernakalant (b) using evolved w-TAs. 

Reductive amination of the ramatroban ketone precursor using sterically demanding (/ )- -phenylethylamine as amine donor. 

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