Appetitive strategy

Searching or appetitive strategy is used here to delineate behavior patterns that are characterized generally by increased locomotion and lowered thresholds to stimuli inducing the next behavior, in this case orientation toward a chemical. Appetitive behavior is thus defined teleologically, and as a consequence currently is avoided by most behaviorists. But it has heuristic value and I do not know of a suitable, non-teleological replacement term. 

The sequence of alkylation followed by reduction gives an amine and the special advantage of this strategy is that it can lead to r-alkyl amines. The appetite suppressant 15 can be disconnected next to the tertiary centre after the amines are changed to a nitro-compound 16. 2-Nitropropane 18 is available. 

McCarty, M.F. (1 995) Promotion of hepatic lipid oxidation and gluconeogenesis - a strategy for appetite control. Medical Hypotheses 44, 278-286. 

Our appetite for simplicity has caused us to compress the chaos of the 60s into one monolithic Youth Revolt. But there were two philosophies then among the revolutionaries on how the world might be remade. One path, endorsed by the political activists, advocated a traditional Western strategy seizing political power and using that vantage to raise consciousness and save the world. The other path proposed an attack on consciousness itself using a controversial and soon outlawed family of psychochemicals—the psychedelics. 

The most common adverse effects of stimulants and their management strategies are listed in Table 61-4. Growth suppression or delay is a possibility. Proposed mechanisms of stimulant effects on growth include alterations in growth hormone secretion and suppression of appetite leading to reduced caloric intake. One study measured the... 

This approach is particularly useful for primary amines bearing /-alkyl groups as few, if any, of our previous methods Chapter 8) can be used for these compounds. The appetite suppressant Chlorphentermine (7) is therefore best made from nitro compound (8). The best disconnection is then to the benzyl halide (9) and 2-nitropropane (10) these are both available and it is good strategy to break off as large a fragment as possible. 

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