Appetite, reduced

Signs and Symptoms Initial symptoms include fever, watery eyes, increased nasal secretions, drooling (ptyalism), diarrhea, loss of appetite, reduced milk production, depression, and reluctance to move. This is followed by the eruption of various sized skin nodules that may cover the whole body. They can be found on any part of the body but are most numerous on the head and neck, perineum, genitalia and udder, and the limbs. The nodules are painful and involve all layers of the skin. Skin lesions may show scab formation. Regional lymph nodes are enlarged and full of fluid. Secondary bacterial infection can complicate healing and recovery. Final resolution of lesions may take 2-6 months, and nodules can remain visible 1-2 years. 

Mechanism of action Reduces absorption of fats since triglycerides not split Reduces appetite Reduces appetite... 

Pharmaceutical companies developed diet pills with amphetamine congeners, chemicals that were similar to amphetamines. Although not as potent as amphetamines, these pills had more of an appetite-reducing effect than caffeine. 

Bjurulf P, Carlstrom S, Rorsman G. Oberex, a new appetite-reducing agent. Acta Med Scand 1967 182(3) 273-80. 

The new compounds according to the invention are valuable appetite-reducers which have shown themselves to be superior to similarly constituted known compounds. 

The new compounds show a particularly desirable ratio of appetite-reducing to central nervous system-stimulating activity, particularly through lower toxicity than similarly constituted active appetite-reducing substances. The new compounds may be administered orally and have a long duration of action they may be used in humans at a dose level of about 0.1 to 3.0 mg/kg, preferably from 0.3 to 1.5 mg/kg daily. Particularly useful compounds, from the point of view of their physiological activity include l- p-chlorophenyl)-2-aminobutane, l-(p-chloro-phenyl)-2-methylaminobutane, l-(p-chlorophenyl)-2-aminobutane. 

Kaufmann, A.,A. Manufacture of Glycidic Acids 1932 US 1,858,551 Kefalas A.,S Appetite-reducing Compositions Comprising Phenylamino Propane Derivatives 1962 GB 906,331... 

Abdomen - pain Abdomen - tender Appetite - reduced (anorexia)... 

Sibutramine may be useful in patients where the obese state is characterised by overeating and snacking because of its appetite reducing effects. Sibutramine should not be used in patients with uncontrolled hypertension or with tachy-arrhythmia. Rimonabant may be preferred in obese patients with the metabolic syndrome particularly in those with low HDL and high triglyceride. Because of few data rimonabant should be avoided in patients with psychiatric illness, particularly in patients with major depressions and in patients in antidepressive treatment. These suggestions are not evidence based but the recommendations that can be used until more direct head-to-head investigations have been performed. 

Toxicity test of rats and mice all showed that no death, increase of serum GOT and abnormal symptoms happened, in the animals (3.2g/Kg).(9) After three rabbits had taken ss (5mg/Kg/day) for four weeks, it was found that their appetite reduced, their weight increased slowly and their hematological, liver and Iddney fiinction examinations and vital organ microscopy had no abnormity.(8)... 

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