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Aporphine alkaloids binding

Cassytha filiformis L., mentioned earlier, contains aporphine alkaloids such as actin odaphnine, cassythine, and dicentrine, which effectively bind to DNA and behave as typical intercalating agents and interfere with the catalytic activity of topoisomerases (3,10,11). [Pg.176]

Arana, G.W. Lamont, J.S. Baldessarini, R.J. Teicher, M.H. Neumeyer, J.L. Cohen, B.M. (1984) Binding of [3H]apomorphine to an aporphine binding site as well as to dopamine sites in tissue from bovine caudate nucleus. Neuropharmacology 23, 885-892. Kelly, P.H. Miller, R.J. Neumeyer, J.L. (1976) Aporphines. 16. Action of aporphine alkaloids on locomotor activity in rats with 6-hydroxydopamine lesions of the nucleus accumbens. Eur. J. Pharmacol. 35, 85-92. [Pg.123]

Most information regarding the action of alkaloids relates to the alpha 2 receptor, where the indole alkaloids yohimbine and its isomer, rauwolscine, bind with high affinity and block the receptor [187, 191]. Dihydrocorynantheine, an indole alkaloid of similar structure preferentially binds to the alpha 1 receptor, as do some aporphines [192,... [Pg.19]

See other pages where Aporphine alkaloids binding is mentioned: [Pg.145]    [Pg.132]    [Pg.1038]    [Pg.143]    [Pg.531]    [Pg.130]    [Pg.198]    [Pg.179]    [Pg.22]   
See also in sourсe #XX -- [ Pg.156 ]



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