Aporphine alkaloids apomorphine

Apomorphine 169, 170 Aporphine alkaloids 151, 152 Apparicine 16, 147 Arborine 105, 106 Arctigenin 39 Aren tin 41, 47 Arecaidine 86... 

Apomorphine was the most potent of the protein kinase inhibitors (IC50 for PKA-catalytic subunit 1 pM). However, the methylated aporphine alkaloid analogues of apomorphine such as bulbocapnine, isocorydine, glaucine and (+)-boldine were either inactive or poor inhibitors of this en2 yme. 

Arana, G.W. Lamont, J.S. Baldessarini, R.J. Teicher, M.H. Neumeyer, J.L. Cohen, B.M. (1984) Binding of [3H]apomorphine to an aporphine binding site as well as to dopamine sites in tissue from bovine caudate nucleus. Neuropharmacology 23, 885-892. Kelly, P.H. Miller, R.J. Neumeyer, J.L. (1976) Aporphines. 16. Action of aporphine alkaloids on locomotor activity in rats with 6-hydroxydopamine lesions of the nucleus accumbens. Eur. J. Pharmacol. 35, 85-92. 

The metabolism of apocodeine to apomorphine and norapomorphine was shown to occur in rats. The clinical application of apomorphine has been discussed. The synthesis and pharmacological testing of several aporphine alkaloid analogues have been reported. The pharmacology of liriodenine, thalicminine, corydine, and isocorydine hydrochloride has been investigated. The synthesis of tritium- and deuterium-labelled apomorphine has been reported. " Under controlled conditions, exclusive introduction of label into the catechol ring of the molecule was achieved. 

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